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Clinical Presentation, Demographic And Pathological Pattern Of Primary Thyroid Carcinoma
Endocrinology
Histological Patterns: This includes different histological types of thyroid carcinoma including Papillary, Anaplastic, Follicular and medullary thyroid carcinoma.
HYPOTHESIS:
There is no association between different histological pattern of primary thyroid carcinoma and demographic features like age, sex ethnic origin (sindhi, balochi, pathan, urdu speaking and others).
MATERIAL AND METHODS:
SETTINGS: Department of Medicine and Endocrine clinic Aga Khan University Hospital Karachi.
DURATION: Minimum of six months.
SAMPLE SIZE: 40 cases of primary thyroid carcinoma.
SAMPLING TECHNIQUE: Non probability convenience sampling.
STUDY DESIGN: Crossectional Comparative study
INCLUSION CRITERIA:
1. Biopsy proven cases of Primary thyroid Carcinoma.
2. Patients of either sex and of any age.
EXCLUSION CRITERIA:
1. Patients with secondary metastasis in thyroid.
2. Those who refuse for the consent
DATA COLLECTION PROCEDURE:
This study will include data generated after the approval of synopsis on patients who are histologically diagnosed case of Primary Thyroid Carcinoma admitted in the department of Medicine (ward) and those who will be following in Endocrine clinic Aga Khan University Hospital Karachi. Detailed history and examination of the patient will be done, all the details will be entered on a pre-approved proforma by a same person who is taking detailed history and examinaation after informed consent, including related demographic features like name, age, sex, medical record (MR) #, address, date, phone #, Ethnic Origin such as sindhi, punjabi, balochi, pathan, urdu speaking, others; clinical presentation like neck mass/swelling, recent change of voice, stridor, dysphagia, dysponea, cervical lymphadenopathy, weight Loss, symptoms of superior vena caval syndrome, eye signs, sign and symptoms of metastasis, paraneoplastic syndrome: and others; out of the following only necessary laboratory investigations as per requirement of the individual case including TSH (Thyroid Stimulating Hormone), FT4 (Free Thyroxine Levels), Hb (Hemoglobin), serum corrected calcium, FNAC (Fine Needle Aspiration Cytology), computed tomography of Neck and Chest, ultrasound Abdomen/computed tomography of Abdomen will be entered on the proforma along with associated factors like history of Head and neck irradiation, family history of thyroid carcinoma and history of other endocrine diseases. Required laboratory tests including diagnostic histopathology (histological types including Anaplastic, Papillary, Medullary and Follicular thyroid carcinoma) will be done at Aga Khan University Hospital (AKUH) Karachi.
DATA ANALYSIS:
Statistical package of social science SPSS version 13.0 will be used for data entry and data analysis. Results will be presented as numbers (percentage) for qualitative variables like gender, neck swelling, recent change of voice, stridor, dysphagia etc. Mean with standard deviation will be reported for quantitative variables that is age and laboratory parameters.
Univariant analysis will be performed by using Pearson Chi-Square or Fischer exact test to check the association of FNAC (Fine Needle Aspiration Cytology) results with other co-variants like gender. Whereas Kruskalwallis test will be used to compare the median among different groups of thyroid carcinoma, P value of <0.05 will be considered as statistically significant.
PROFORMA:
A. BIODATA:
A1. Name: A2. Age:
A3. Sex: A4. MR #:
A5. Address: A6. Date:
A7. Phone #:
A8. Ethnic Origin (sindhi, punjabi, balochi, pathan, urdu speaking, others):
B. HISTORY:
B1. H/O Head and neck irradiation:
B2. Family History of Thyroid Carcinoma:
B3. H/O other Endocrine Diseases:
C. SIGNS AND SYMPTOMS:
PRESENT / ABSENT
C1. Neck Swelling/mass:
C2. Recent change of voice:
C3. Stridor:
C4. Dysphagia:
C5. Dysponea:
C6. Cervical Lymphadenopathy:
C7. Weight Loss:
C8. Symptoms of SVC
(Superior vena caval) syndrome:
C9. Eye signs:
C10. Sign and symptoms of metastasis:
C11. Paraneoplastic syndrome:
C12. Others:
D. INVESTIGATIONS:
D1. TSH
D2. .FT4
D3. Hemoglobin
D4. Corrected calcium:
D5. FNAC
D6. CT Neck and Chest
D7. Ultra Sound Abdomen/CT Abdomen:
HYPOTHESIS:
There is no association between different histological pattern of primary thyroid carcinoma and demographic features like age, sex ethnic origin (sindhi, balochi, pathan, urdu speaking and others).
MATERIAL AND METHODS:
SETTINGS: Department of Medicine and Endocrine clinic Aga Khan University Hospital Karachi.
DURATION: Minimum of six months.
SAMPLE SIZE: 40 cases of primary thyroid carcinoma.
SAMPLING TECHNIQUE: Non probability convenience sampling.
STUDY DESIGN: Crossectional Comparative study
INCLUSION CRITERIA:
1. Biopsy proven cases of Primary thyroid Carcinoma.
2. Patients of either sex and of any age.
EXCLUSION CRITERIA:
1. Patients with secondary metastasis in thyroid.
2. Those who refuse for the consent
DATA COLLECTION PROCEDURE:
This study will include data generated after the approval of synopsis on patients who are histologically diagnosed case of Primary Thyroid Carcinoma admitted in the department of Medicine (ward) and those who will be following in Endocrine clinic Aga Khan University Hospital Karachi. Detailed history and examination of the patient will be done, all the details will be entered on a pre-approved proforma by a same person who is taking detailed history and examinaation after informed consent, including related demographic features like name, age, sex, medical record (MR) #, address, date, phone #, Ethnic Origin such as sindhi, punjabi, balochi, pathan, urdu speaking, others; clinical presentation like neck mass/swelling, recent change of voice, stridor, dysphagia, dysponea, cervical lymphadenopathy, weight Loss, symptoms of superior vena caval syndrome, eye signs, sign and symptoms of metastasis, paraneoplastic syndrome: and others; out of the following only necessary laboratory investigations as per requirement of the individual case including TSH (Thyroid Stimulating Hormone), FT4 (Free Thyroxine Levels), Hb (Hemoglobin), serum corrected calcium, FNAC (Fine Needle Aspiration Cytology), computed tomography of Neck and Chest, ultrasound Abdomen/computed tomography of Abdomen will be entered on the proforma along with associated factors like history of Head and neck irradiation, family history of thyroid carcinoma and history of other endocrine diseases. Required laboratory tests including diagnostic histopathology (histological types including Anaplastic, Papillary, Medullary and Follicular thyroid carcinoma) will be done at Aga Khan University Hospital (AKUH) Karachi.
DATA ANALYSIS:
Statistical package of social science SPSS version 13.0 will be used for data entry and data analysis. Results will be presented as numbers (percentage) for qualitative variables like gender, neck swelling, recent change of voice, stridor, dysphagia etc. Mean with standard deviation will be reported for quantitative variables that is age and laboratory parameters.
Univariant analysis will be performed by using Pearson Chi-Square or Fischer exact test to check the association of FNAC (Fine Needle Aspiration Cytology) results with other co-variants like gender. Whereas Kruskalwallis test will be used to compare the median among different groups of thyroid carcinoma, P value of <0.05 will be considered as statistically significant.
PROFORMA:
A. BIODATA:
A1. Name: A2. Age:
A3. Sex: A4. MR #:
A5. Address: A6. Date:
A7. Phone #:
A8. Ethnic Origin (sindhi, punjabi, balochi, pathan, urdu speaking, others):
B. HISTORY:
B1. H/O Head and neck irradiation:
B2. Family History of Thyroid Carcinoma:
B3. H/O other Endocrine Diseases:
C. SIGNS AND SYMPTOMS:
PRESENT / ABSENT
C1. Neck Swelling/mass:
C2. Recent change of voice:
C3. Stridor:
C4. Dysphagia:
C5. Dysponea:
C6. Cervical Lymphadenopathy:
C7. Weight Loss:
C8. Symptoms of SVC
(Superior vena caval) syndrome:
C9. Eye signs:
C10. Sign and symptoms of metastasis:
C11. Paraneoplastic syndrome:
C12. Others:
D. INVESTIGATIONS:
D1. TSH
D2. .FT4
D3. Hemoglobin
D4. Corrected calcium:
D5. FNAC
D6. CT Neck and Chest
D7. Ultra Sound Abdomen/CT Abdomen:
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